Your browser doesn't support javascript.
loading
Risk factors for intracranial aneurysm in a Chinese ethnic population / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 1359-1364, 2006.
Artigo em Inglês | WPRIM | ID: wpr-335600
ABSTRACT
<p><b>BACKGROUND</b>Intracranial aneurysm (IAN) is a protruding bubble or a sac on a brain artery that balloons out over time, which may lead to spontaneous subarachnoid hemorrhage (SAH), ultimately disability and mortality. Current research indicates that the disease is due to multiple causes, including environmental factors and various congenital abnormalities of blood vessels. Apart from congenital predisposition, various high-risk factors such as sex, age, hypertension, and atherosclerosis are involved in the formation of intracranial aneurysms. The aim of this study was to investigate the risk factors associated with the formation of sporadic intracranial aneurysms in Chinese Han ethnic patients.</p><p><b>METHODS</b>A total of 251 patients with intracranial aneurysm and 338 patients with other cerebral diseases (control group) were enrolled in this study. Single factor and logistic regression model were used to analyze the association of intracranial aneurysms with age; sex; cigarette smoking; alcohol or cocaine consumption; history of hypertension, coronary artery disease, diabetes mellitus and inherited connective tissue disease; and the levels of fasting blood glucose and blood fat. The data expressed as mean +/- standard deviation were processed with the statistical software SPSS13. Quantitative and qualitative data were analyzed by the independent-sample t test, and the chi-square test respectively. Logistic regression method was used to analyze the multiple factors.</p><p><b>RESULTS</b>In the 251 patients, 163 (64.94%) were at age of 40 to 60 years. Sex (OR, 1.41; 95% CI, 1.01 - 1.96), cigarette smoking (OR, 1.81; 95% CI, 1.06 - 3.10), hypertension (OR, 2.32; 95% CI, 1.30 - 4.16) and fasting blood glucose were significantly associated with intracranial aneurysm (P < 0.05). Intracranial aneurysm was correlated with alcohol consumption, coronary artery disease, and the level of blood lipids (P > 0.05). Using logistic regression analysis, we identified female sex and advanced age as significant risk factors for sporadic intracranial aneurysms.</p><p><b>CONCLUSIONS</b>Sporadic intracranial aneurysms mostly occur in people aged 40 to 60 years. Feminine, cigarette smoking, and hypertension are independent risk factors for the disease, and the gender is the most significant factor. Advanced age can increase the effect of these risk factors.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fumar / Modelos Logísticos / Aneurisma Intracraniano / China / Fatores Sexuais / Estudos Retrospectivos / Fatores de Risco / Fatores Etários / Aterosclerose / Etnologia Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico / Pesquisa qualitativa / Fatores de risco Limite: Adolescente / Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2006 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fumar / Modelos Logísticos / Aneurisma Intracraniano / China / Fatores Sexuais / Estudos Retrospectivos / Fatores de Risco / Fatores Etários / Aterosclerose / Etnologia Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico / Pesquisa qualitativa / Fatores de risco Limite: Adolescente / Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2006 Tipo de documento: Artigo