Function and biological activities of the autotaxin-LPA axis / 生理学报
Acta Physiologica Sinica
;
(6): 601-610, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-335949
ABSTRACT
Autotaxin (ATX), a member of nucleotide pyrophosphatase/phosphodiesterase (NPP) family, is also named as phosphodiesterase Iα (PD-Iα) or NPP2. ATX is the unique member among the NPPs that can function as a lysophospholipase D (lysoPLD), converting lysophosphatidylcholine into lysophosphatidic acid (LPA). LPA acts on specific G-protein-coupled receptors to elicit a wide range of cellular response, including cell proliferation, cell migration and cell contraction, etc. As the major LPA-producing phospholipase, many ATX's features and functions are dependent on the production of LPA. ATX and LPA together form the ATX-LPA functional axis. The present review summarizes the current progress in function and biological activities of ATX-LPA axis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosfolipases
/
Fisiologia
/
Lisofosfolipídeos
/
Lisofosfatidilcolinas
/
Movimento Celular
/
Diester Fosfórico Hidrolases
/
Receptores Acoplados a Proteínas G
/
Proliferação de Células
/
Metabolismo
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2011
Tipo de documento:
Artigo
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