Detection of serum autoantibodies to melanocyte and correlation between melanoma antigen recognized by T-cells and vitiligo in children / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2107-2111, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-336009
ABSTRACT
<p><b>OBJECTIVE</b>To detect the serum levels of melanocyte antibodies and explore the relation between melanoma antigen recognized by T-cells (MART-1) and vitiligo in children.</p><p><b>METHODS</b>The serum samples were collected from children with vitiligo to test the autoantibodies, and divided into low- and high-titer group according to the test results. Melanocytes were incubated with the serum samples, and the changes of melanocyte surface antigen were evaluated using specific MART-1 antibody.</p><p><b>RESULTS</b>The serum melanocyte antibody levels in children with vitiligo were significantly higher than those in normal subjects. The expression level of melanocyte surface antigen MART-1 increased obviously after incubation of the melanocyte with high antibody titer serum samples, and MART-1 was found to specifically bind to specific MART-1 antibody.</p><p><b>CONCLUSION</b>Melanocytes MART-1 may correlate to the autoimmune mechanism in children with vitiligo.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Autoanticorpos
/
Vitiligo
/
Sangue
/
Ensaio de Imunoadsorção Enzimática
/
Linfócitos T
/
Alergia e Imunologia
/
Antígeno MART-1
/
Melanócitos
Tipo de estudo:
Estudo diagnóstico
Limite:
Adolescente
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2009
Tipo de documento:
Artigo
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