Antineoplastic effect of koumine in mice bearing H22 solid tumor / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the antitumor effects of koumine in mice bearing H22 solid tumor and its effect on the immune system of the mice.</p><p><b>METHODS</b>The changes in spleen and tumor weights and blood cell count were observed after koumine treatment in BALB/c athymic mice bearing H22 solid tumor, using normal saline solution and 5-Fu as the controls.</p><p><b>RESULTS</b>Koumine significantly inhibited the tumor growth in a dose-dependent manner. The spleen index and blood cell counts in koumine group showed no significant differences from those in the saline control group, but higher than those in 5-Fu group.</p><p><b>CONCLUSION</b>Koumine can significantly inhibit the growth of H22 solid tumor without obvious inhibitory effect on the immune system in mice.</p>