Acute phase reaction of different macromolecule vascular grafts healing in rat muscle / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 79-84, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-336258
ABSTRACT
To find out which biomaterial had the best biocompatibility, we compared the acute phase reaction of common biomaterials preparing for vascular grafts with the material of polyurethane modified by silk fibroin (SF-PU(11)). After transplanted the materials of dacron, polyterafluoroethylene (e-PTFE), polyurethane (PU), SF-PU(11) in rat muscle for one week, we studied the influence of different biomaterials on the histocompatibility by using rat acute toxicity test, test of local reaction in muscle, tissue section staining, WBC and PLT count. As a result, dacron had the worst histocompatibility. The other biomaterials had slight local inflammatory reaction. The WBC and PLT was nearly the same with the blank except dacron. e-PTFE, pure PU and SF-PU(11) had the better histocompatibility than traditional dacron. Especially SF-PU(11) had the best histocompatibility. Because of the better physical properties and histocompatibility of SF-PU( 11), the prospect of preparing small-diameter vascular grafts with SF-PU was cheerful.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Poliuretanos
/
Desenho de Prótese
/
Materiais Biocompatíveis
/
Teste de Materiais
/
Prótese Vascular
/
Distribuição Aleatória
/
Química
/
Reação de Fase Aguda
/
Ratos Sprague-Dawley
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS