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Prognostic value of P16 gene methylation and P16 protein expression in gastrointestinal stromal tumor / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery ; (12): 372-375, 2007.
Artigo em Chinês | WPRIM | ID: wpr-336441
ABSTRACT
<p><b>OBJECTIVE</b>To study the methylation status of P16 gene promoter and the expression of P16 protein in gastrointestinal stromal tumors(GIST) and to explore the prognostic value.</p><p><b>METHODS</b>Methylation status of the P16 promoter was detected by methylation- specific polymerase chain reaction (MSP) and the expression of P16 protein by immunohistochemistry in 62 patients with GIST.</p><p><b>RESULTS</b>The status of P16 gene methylation and the expression of P16 protein were significantly different among the patients with different subclassification of GIST using Fletcher's scheme (P < 0.05, P < 0.01). And there were significant differences in progressive disease (PD) among various levels of P16 expression (P < 0.01). P16 gene methylation was closely related to P16 protein. P16 gene methylation accounted for 75% in the tumor tissue with less than 50% P16 positive cells, and accounted for only 10% in the tumor tissue with more than 50% P16 positive cells (P< 0.01).</p><p><b>CONCLUSION</b>P16 immunohistochemical assessment can be used as a prognostic index for GIST. The patients with more than 50% fraction of cells with low P16 immunostaining have poor prognosis.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Prognóstico / Seguimentos / Ilhas de CpG / Metilação de DNA / Inibidor p16 de Quinase Dependente de Ciclina / Tumores do Estroma Gastrointestinal / Genética / Metabolismo Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Adolescente / Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Gastrointestinal Surgery Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Prognóstico / Seguimentos / Ilhas de CpG / Metilação de DNA / Inibidor p16 de Quinase Dependente de Ciclina / Tumores do Estroma Gastrointestinal / Genética / Metabolismo Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Adolescente / Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Gastrointestinal Surgery Ano de publicação: 2007 Tipo de documento: Artigo