Stroke Connectome and Its Implications for Cognitive and Behavioral Sequela of Stroke / 대한뇌졸중학회지
Journal of Stroke
;
: 256-267, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-33658
ABSTRACT
Systems-based approaches to neuroscience, using network analysis and the human connectome, have been adopted by many researchers by virtue of recent progress in neuroimaging and computational technologies. Various neurological disorders have been evaluated from a network perspective, including stroke, Alzheimer's disease, Parkinson's disease, and traumatic brain injury. Until now, dynamic processes after stroke and during recovery were investigated through multimodal neuroimaging techniques. Many studies have shown disruptions in structural and functional connectivity, including in large-scale neural networks, in patients with stroke sequela such as motor weakness, aphasia, hemianopia, neglect, and general cognitive dysfunction. A connectome-based approach might shed light on the underlying mechanisms of stroke sequela and the recovery process, and could identify candidates for individualized rehabilitation programs. In this review, we briefly outline the basic concepts of structural and functional connectivity, and the connectome. Then, we explore current evidence regarding how stroke lesions cause changes in connectivity and network architecture parameters. Finally, the clinical implications of perspectives on the connectome are discussed in relation to the cognitive and behavioral sequela of stroke.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Afasia
/
Doença de Parkinson
/
Reabilitação
/
Lesões Encefálicas
/
Neurociências
/
Hemianopsia
/
Acidente Vascular Cerebral
/
Virtudes
/
Imagem de Tensor de Difusão
/
Doença de Alzheimer
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Stroke
Ano de publicação:
2015
Tipo de documento:
Artigo
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