Characteristic of microglial activation of hippocampus in experimental epileptic rats / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 310-314, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-336791
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the characteristics of microglial activation of hippocampus in experimental epileptic rats.</p><p><b>METHODS</b>Morphological changes and proliferation of OX-42 positive cells were compared at different time points after status of epilepticus (SE) in lithium-pilocarpine induced epileptic rats.</p><p><b>RESULTS</b>OX-42 positive cells were activated after SE, which increased to a peak at 3-7 d and in a relatively stable state at 7-14 d; then gradually decreased after 14d and returned to slightly higher level than previously at 21 d.</p><p><b>CONCLUSION</b>Inflammatory injury, microglial activation and cell proliferation are closely related after seizures, microglial activation may be an important mechanism in the inflammatory injury of epilepsy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Estado Epiléptico
/
Ratos Sprague-Dawley
/
Microglia
/
Biologia Celular
/
Proliferação de Células
/
Modelos Animais de Doenças
/
Hipocampo
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2012
Tipo de documento:
Artigo
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