Construction of a multiple-scale implant surface with super-hydrophilicity / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To construct a multiple-scale organized implant surface with super-hydrophilicity.</p><p><b>METHODS</b>The SiC paper polished titanium disc was sandblasted and treated with HF/HNO₃ and HCl/H₂SO₄, then acid-etched with H₂SO₄/H₂O₂. The physicochemical properties of the surfaces were characterized by scanning electron microscope, static state contact angle and X-ray diffraction. MC3T3-E1 cells were used to evaluate the effects of the surface on the cell adhesion, proliferation and differentiation.</p><p><b>RESULTS</b>The acid-etching process with a mixture of H₂SO₄/H₂O₂ superimposed the nano-scale structure on the micro-scale texture. The multiple-scale implant surface promoted its hydrophilicity and was more favorable to the responses of osteoprogenitor cells, characterized by increased DNA content, enhanced ALP activity and promoted OC production.</p><p><b>CONCLUSION</b>A multiple-scale implant surface with super-hydrophilicity has been constructed in this study, which facilitates cell proliferation and adhesion.</p>