Effect of p53 gene knockout on cell migration / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1132-1135, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-337313
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of p53 gene in serum-induced cell migration.</p><p><b>METHODS</b>The effects of p53 knockout on serum-induced formation of lamellipodia and cell migration were observed using Transwell cell migration system.</p><p><b>RESULTS</b>p53(+/+) cells developed lamellipodia upon serum stimulation and showed enhanced activity of cell migration, but these effects were not observed in p53 knockout cells after serum stimulation.</p><p><b>CONCLUSION</b>p53 plays a role in serum-induced cell migration.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pseudópodes
/
Linhagem Celular
/
Movimento Celular
/
Regulação da Expressão Gênica
/
Proteína Supressora de Tumor p53
/
Soro
/
Técnicas de Inativação de Genes
/
Genética
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2007
Tipo de documento:
Artigo
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