Preliminary study of neuroendocrine differentiation and its mechanism in ovarian epithelial tumors / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1081-1083, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-337319
ABSTRACT
<p><b>OBJECTIVE</b>To investigate neuroendocrine differentiation and its mechanism in ovarian epithelial tumors.</p><p><b>METHODS</b>Neuroendocrine (NE) cells were identified by immunohistochemical staining for chromogranin A and synaptophysin in 79 cases of ovarian epithelial tumor and 22 cases of normal ovary. Double-labeling technique was used for simultaneous detection of CgA and epithelial membrane antigean (EMA), and the staining intensity was quantitatively evaluated using an image analysis system.</p><p><b>RESULTS</b>The positive staining rate for CgA and SYN in ovarian epithelial tumors was 59.4% and 65.36%, respectively, which was higher than that in normal ovary (P=0.000), in which numerous NE cells were found. Both the number and staining intensity of NE cells in ovarian epithelial tumor were increased as compared with normal ovary. Cells co-expressing CgA and EMA were detected in the ovarian epithelial tumors.</p><p><b>CONCLUSION</b>The presence of NE cells in ovarian epithelial tumor suggests heterogeneity of the tumors, and the occurrence of "multidirectional differentiation cells" within the these tumors indicates that NE cells might derive from malignant cells with multidirectional differentiation capacity.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Ovarianas
/
Ovário
/
Patologia
/
Imuno-Histoquímica
/
Estudos de Casos e Controles
/
Regulação Neoplásica da Expressão Gênica
/
Diferenciação Celular
/
Neoplasias Epiteliais e Glandulares
/
Biologia Celular
/
Células Neuroendócrinas
Tipo de estudo:
Estudo observacional
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2007
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS