Association of XAGE-1b gene expression with clinical characteristics of non-small cell lung cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 966-968, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-337348
ABSTRACT
<p><b>OBJECTIVE</b>To explore the association between XAGE-1b gene expression and the clinical characteristics of non-small cell lung cancer (NSCLC).</p><p><b>METHODS</b>Tumor tissue and adjacent normal lung tissue specimens were obtained surgically from 30 patients with resectable NSCLC, from which the total RNA was extracted for RT-PCR to amplify full-length XAGE-1b gene. The products of RT-PCR were identified by electrophoresis and sequencing. The expression of XAGE-1b gene and its association with the clinical characteristics of the patients were analyzed.</p><p><b>RESULTS</b>In the 30 tumor tissue specimens, the expression rate of XAGE-1b gene was 40%, but none of the normal lung tissues expressed this gene. The gene expression was not related to the patients' age, gender, tumor differentiation or clinical stages, but showed significant correlation to their pathological classification. The expression rate of XAGE-1b gene in adenocarcinoma was much higher than that in tumors of other pathological types (61.1% vs 8.3%, P=0.015). XAGE-1b gene expression tended to increase with the TNM stages, which, however, failed to find statistical data support (P>0.05).</p><p><b>CONCLUSIONS</b>XAGE-1b gene is highly expressed in lung adenocarcinoma, and can be an ideal target for tumor immunotherapy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
RNA Mensageiro
/
Regulação Neoplásica da Expressão Gênica
/
Carcinoma Pulmonar de Células não Pequenas
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Genética
/
Neoplasias Pulmonares
/
Metabolismo
/
Antígenos de Neoplasias
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2007
Tipo de documento:
Artigo
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