Restraining effects of acupuncture on photoreceptor cell apoptosis in rats with retinitis pigmentosa induced by N-methyl-N-nitrosourea / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 43-45, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-337553
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of acupuncture on photoreceptor cell apoptosis in rats with retinitis pigmentosa induced by N-methyl-N-nitrosourea (MNU).</p><p><b>METHODS</b>Fifty-day-old female SD rats were established into model of retinitis pigmentosa by once intraperitoneal injection of 50 mg/kg MNU, and randomly grouped to the acupuncture group and the model group for observing the cell apoptosis in rats and compared with that in normal rats at the corresponding time points.</p><p><b>RESULTS</b>Acupuncture showed no effect on cell apoptosis at its peak of occurring, apoptotic phenomena still could be seen on days 5 and 7, but it was significantly less in the acupuncture group than in the model group (P < 0.01). Moreover, acupuncture showed a restraining effect on the up-regulation of caspase-3 activity.</p><p><b>CONCLUSION</b>Acupuncture can restrain the MNU induced apoptosis of photoreceptor cells, the effect is correlated, to a certain degree, with the status of the apoptosis occurrence.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Células Fotorreceptoras
/
Fisiologia
/
Terapêutica
/
Distribuição Aleatória
/
Terapia por Acupuntura
/
Retinose Pigmentar
/
Ratos Sprague-Dawley
/
Apoptose
/
Caspase 3
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2009
Tipo de documento:
Artigo
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