Recent advance on blood group antigen modification of porcine erythrocytes / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 273-276, 2002.
Article
em Zh
| WPRIM
| ID: wpr-337592
Biblioteca responsável:
WPRO
ABSTRACT
Advances in the field of xenotransplantation raise the intriguing possibility of using porcine red blood cells (pRBCs) as an alternative source for blood transfusion. Serologically, pRBCs share a number of characteristics with human red blood cells (RBCs), so pRBCs are considered the most likely donor for xenotransfusion. However, xenoantigens on porcine erythrocytes play major roles in antibody-mediated RBC destruction. Although the alphaGal epitope (Galalpha1, 3Galbeta1, 4GalNAc-R) is the major xenoantigen on porcine erythrocytes and is responsible for the binding of the majority of human natural antibodies, other non-alphaGal xenoantigens have been identified. The importance of these non-alphaGal xenoantigens in binding human natural antibodies and subsequently triggering immunological responses cannot be underestimated.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Suínos
/
Transplante Heterólogo
/
Antígenos de Grupos Sanguíneos
/
Transfusão de Eritrócitos
/
Biologia Celular
/
Alergia e Imunologia
/
Eritrócitos
/
Métodos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2002
Tipo de documento:
Article