Histopathologic Features and Immunophenotype of 19 Primary Cutaneous Lymphomas
Korean Journal of Pathology
;
: 1111-1119, 1999.
Artigo
em Coreano
| WPRIM
| ID: wpr-33764
ABSTRACT
The diagnosis of primary cutaneous lymphoma is based on a combination of clinical, histological, immunophenotypic and genetic criteria. Nineteen cases of primary cutaneous lymphomas were studied for clinicopathologic, immunophenotypic, and genetic features. Seventeen (89%) cases were T cell origin and two cases (11%) were B cell origin. CD30-positive cutaneous lymphoproliferative disorder was the most frequent subtype, occupying 42% (8 cases) of the cases. CD8 was positive in 5 cases consisting of 3 cutaneous T cell lymphomas and 2 anaplastic large cell lymphomas. CD4 was positive in 2 cases of mycosis fungoides and 3 cases of lymphomatoid papulosis. Six (67%) of 9 cases of cutaneous T cell lymphoma were positive for TIA-1. Ten (83%) out of 12 cases showed clonal rearrangements of TCR gamma genes, however, one T/NK cell lymphoma and one anaplastic large cell lymphoma did not. EBV association was detected only in T/NK cell lymphomas among 10 cases examined. In conclusion, our study showed higher proportion of CD30-positive lymphoproliferative disorders and less frequent mycosis fungoides in Korea compared to the incidences in Western countries. Our immunostaining results suggested that mycosis fungoides and lymphomatoid papulosis are CD4-positive T cell origin, however, the remaining primary cutaneous T cell lymphoma is predominantly CD8-positive cytotoxic T cell origin.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Incidência
/
Linfoma Cutâneo de Células T
/
Micose Fungoide
/
Papulose Linfomatoide
/
Linfoma Anaplásico de Células Grandes
/
Herpesvirus Humano 4
/
Genes Codificadores da Cadeia gama de Receptores de Linfócitos T
/
Diagnóstico
/
Coreia (Geográfico)
/
Linfoma
Tipo de estudo:
Estudo diagnóstico
/
Estudo de incidência
/
Estudo prognóstico
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Journal of Pathology
Ano de publicação:
1999
Tipo de documento:
Artigo
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