Your browser doesn't support javascript.
loading
Role of interleukin-18 in pathogenesis of acute graft-versus-host disease / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 452-454, 2002.
Artigo em Chinês | WPRIM | ID: wpr-337648
ABSTRACT
To investigate the relationship between interleukin-18 (IL-18) and human acute graft-versus-host disease (aGVHD), 26 patients undergoing allogeneic peripheral blood stem cell transplantation (allo-PBSCT) were included in this study. IL-18 secreted by peripheral blood mononuclear cells (MNCs) was measured by enzyme-linked immunosorbent assay (ELISA) before transplantation and during aGVHD. The results showed that grade I GVHD and grades III-IV GVHD developed in 10 and 5 cases, respectively. The levels in the supernatants of MNCs from patients with aGVHD were significantly higher than those in the cases without aGVHD. The levels of IL-18 were correlated with the severity of aGVHD. It is concluded that IL-18 plays an important role in the development of aGVHD.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Terapêutica / Leucemia / Doença Aguda / Interleucina-18 / Transplante de Células-Tronco de Sangue Periférico / Doença Enxerto-Hospedeiro / Hematopoese / Infecções Tipo de estudo: Estudo de etiologia Limite: Adolescente / Adulto / Criança / Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2002 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Terapêutica / Leucemia / Doença Aguda / Interleucina-18 / Transplante de Células-Tronco de Sangue Periférico / Doença Enxerto-Hospedeiro / Hematopoese / Infecções Tipo de estudo: Estudo de etiologia Limite: Adolescente / Adulto / Criança / Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2002 Tipo de documento: Artigo