Role of interleukin-18 in pathogenesis of acute graft-versus-host disease / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 452-454, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-337648
ABSTRACT
To investigate the relationship between interleukin-18 (IL-18) and human acute graft-versus-host disease (aGVHD), 26 patients undergoing allogeneic peripheral blood stem cell transplantation (allo-PBSCT) were included in this study. IL-18 secreted by peripheral blood mononuclear cells (MNCs) was measured by enzyme-linked immunosorbent assay (ELISA) before transplantation and during aGVHD. The results showed that grade I GVHD and grades III-IV GVHD developed in 10 and 5 cases, respectively. The levels in the supernatants of MNCs from patients with aGVHD were significantly higher than those in the cases without aGVHD. The levels of IL-18 were correlated with the severity of aGVHD. It is concluded that IL-18 plays an important role in the development of aGVHD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Terapêutica
/
Leucemia
/
Doença Aguda
/
Interleucina-18
/
Transplante de Células-Tronco de Sangue Periférico
/
Doença Enxerto-Hospedeiro
/
Hematopoese
/
Infecções
Tipo de estudo:
Estudo de etiologia
Limite:
Adolescente
/
Adulto
/
Criança
/
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2002
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS