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The expression of a novel estrogen receptor, GPR30, in epithelial ovarian carcinoma and its correlation with MMP-9 / 生理学报
Acta Physiologica Sinica ; (6): 524-528, 2010.
Artigo em Chinês | WPRIM | ID: wpr-337717
ABSTRACT
The aim of the present study is to investigate the expression of a novel estrogen receptor, G protein-coupled receptor 30 (GPR30) and its correlation with matrix metalloproteinases-9 (MMP-9) in epithelial ovarian cancer (EOC). Ovary tissues were obtained from 39 female patients, including 30 cases of EOC and 9 cases of benign ovarian tumor. Four normal ovary tissues were used as control. Immunohistochemical staining was used to detect the expressions of GPR30 and MMP-9. Chi square test, Fisher's exact test and Spearman's rank correlation analysis were used for statistical analysis. The results showed that GPR30 overexpression rate in EOC cases was significantly higher than those in benign ovarian tumor and normal ovary cases. Whereas MMP-9 overexpression rate in EOC cases was significantly higher than that in normal ovary cases, without any difference to that in benign ovarian tumor cases. To demonstrate the relationship between GPR30 and clinicopathological variables of EOC, we further analyzed the pathology type, FIGO stage and age of patients sampled in our study. The analysis showed there were significant differences of GPR30 overexpression rate among various pathology types and different FIGO stages (P<0.05), and no significant difference of both GPR30 and MMP-9 among three age groups (P>0.05). Moreover, GPR30 expression was positively correlated with MMP-9 (r(s)=1.000, P=0.002). These results suggest that GPR30 may be involved in the invasion and metastasis of EOC, being a potential index of EOC early diagnosis and malignancy grade prediction.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Ovarianas / Biomarcadores / Receptores de Estrogênio / Cistadenocarcinoma Seroso / Neoplasias Epiteliais e Glandulares / Metaloproteinase 9 da Matriz / Receptores Acoplados a Proteínas G / Metabolismo Tipo de estudo: Estudo prognóstico / Estudo de rastreamento Limite: Adulto / Idoso / Feminino / Humanos Idioma: Chinês Revista: Acta Physiologica Sinica Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Ovarianas / Biomarcadores / Receptores de Estrogênio / Cistadenocarcinoma Seroso / Neoplasias Epiteliais e Glandulares / Metaloproteinase 9 da Matriz / Receptores Acoplados a Proteínas G / Metabolismo Tipo de estudo: Estudo prognóstico / Estudo de rastreamento Limite: Adulto / Idoso / Feminino / Humanos Idioma: Chinês Revista: Acta Physiologica Sinica Ano de publicação: 2010 Tipo de documento: Artigo