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Changes of gamma-aminobutyric acid and glycine released in the medial vestibular nucleus following acute hypotension in conscious rats / 生理学报
Acta Physiologica Sinica ; (6): 30-34, 2010.
Artigo em Chinês | WPRIM | ID: wpr-337783
ABSTRACT
To understand whether some amino acids in the medial vestibular nucleus (MVN) of conscious rats are involved in the regulation of blood pressure, microdialysis technique and high performance liquid chromatography (HPLC) were used to measure the changes of gamma-aminobutyric acid (GABA) and glycine (Gly) in this central area. Wistar rats (250-350 g) were randomly divided into three experimental groups the control group with intact labyrinths; the ipsilateral MVN of unilateral labyrinthectomy (UL); contralateral MVN of the UL. Acute hypotension was induced by intravenous infusion of sodium nitroprusside (SNP). Unilateral chemical labyrinthectomy was performed 14 days before the start of the experiment to eliminate afferent signals from the peripheral vestibular receptors in the inner ear. Blood pressure decreased by 30% after SNP injection. In the control group, GABA and Gly release reduced to 43.53%+/-6.58% (P<0.01) and 62.24%+/-7.51% (P<0.01) respectively in the MVN following SNP-induced acute hypotension in conscious rats. In the contralateral MVN of UL, GABA and Gly release also reduced to 45.85%+/-17.27% (P<0.01) and 73.30%+/-3.00% (P<0.01) respectively following SNP-induced acute hypotension in conscious rats. In contrast, in the ipsilateral MVN of UL, GABA and Gly releases were not changed following SNP-induced acute hypotension in conscious rats. These results suggest that the SNP-induced acute hypotension may influence the activity of the neurons in the MVN by the afferent impulses from the peripheral vestibular organ, and that GABA and Gly may be involved in this process.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Cirurgia Geral / Núcleos Vestibulares / Distribuição Aleatória / Doença Aguda / Cromatografia Líquida de Alta Pressão / Ratos Wistar / Microdiálise / Ácido gama-Aminobutírico / Glicina Limite: Animais Idioma: Chinês Revista: Acta Physiologica Sinica Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Cirurgia Geral / Núcleos Vestibulares / Distribuição Aleatória / Doença Aguda / Cromatografia Líquida de Alta Pressão / Ratos Wistar / Microdiálise / Ácido gama-Aminobutírico / Glicina Limite: Animais Idioma: Chinês Revista: Acta Physiologica Sinica Ano de publicação: 2010 Tipo de documento: Artigo