Coexistence of tuberous sclerosis complex and malignant melanoma
Singapore medical journal
;
: e233-5, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-337832
ABSTRACT
Tuberous sclerosis complex (TSC) is a multisystem genetic disorder characterised by widespread hamartomas in organs such as the skin, brain, heart, lung, liver and kidney. Although associations of TSC with hamartomas, angiomyolipomas and fibromas have been reported, there has been no report of its association with malignant melanoma. Herein, we describe a 31-year-old man with malignant melanoma associated with TSC. The patient had a history of epilepsia, multiple hypomelanotic macules, periungual fibromas and multiple hepatic lesions. Malignant melanoma was diagnosed by hepatic biopsy. To the best of our knowledge, this is the first report of malignant melanoma coexisting with TSC in the literature. We also present and discuss the imaging findings, prognosis, underlying mechanisms and practical approaches in relation to the disease.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Cutâneas
/
Terapêutica
/
Esclerose Tuberosa
/
Biópsia por Agulha
/
Imuno-Histoquímica
/
Imageamento por Ressonância Magnética
/
Tomografia Computadorizada por Raios X
/
Seguimentos
/
Medição de Risco
/
Doenças Raras
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Singapore medical journal
Ano de publicação:
2013
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS