Inflammatory skin response to photochemotherapy: ear swelling response in C57BL mouse model / 대한피부과학회지
Korean Journal of Dermatology
;
: 608-615, 1992.
Artigo
em Coreano
| WPRIM
| ID: wpr-33797
ABSTRACT
We have observed the dark effect of 8-methoxypsoralen(8-M(P) on the viability and DNA synthesis in human lymphocyte cultures after stimulaticn with phytohemagglutinin (PHA) in the absence of ultraviolet A radiation. The concentratioiis of 8-MOP was 0.5-32 ug/ml. We have also measured the LDH activity in supernatant. of lymphocyte cultures treated with 8-MOP. The results were as follows 1. There was no 8-MOP dose-dependent decrease in the viability of lymphocytes up to 8- MOP 32pg/ml. 2. There was a 8-MOP dose-dependent decrease in PHA-induced DNA synthesis of lymphocytes from the concentration of 8-MOP 2 ug/ml. 3. There was a time-dependent decrease in PHA-induced DNA synthesis of lymphocytes at the concentration of 8-MOP 32 ug/ml. 4. There was no LDH release in supernatant of lymphocyte ciltu es after incubation with 8-MOP up to 8-MOP 32ug/ml.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fotoquimioterapia
/
Pele
/
DNA
/
Linfócitos
/
Orelha
/
Metoxaleno
/
Camundongos Endogâmicos C57BL
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
1992
Tipo de documento:
Artigo
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