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Systematic review of Shuxuetong injection for progressive ischaemic stroke / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 2774-2778, 2012.
Artigo em Chinês | WPRIM | ID: wpr-338020
ABSTRACT
<p><b>OBJECTIVE</b>To assess the clinical efficacy and safety of Shuxuetong injection against progressive ischaemic stroke.</p><p><b>METHOD</b>Randomized controlled trials (RCTs) and quasi randomized controlled trials (quasi-RCTs), which focused on treating patients with progressive ischaemic stroke using Shuxuetong injection were identified from Cochrane library, Medline, EMbase, CBM database, CNKI database, VIP database and Wanfang database. Data was extracted and evaluated with designed form. RevMan 5.1 software was used for data analysis.</p><p><b>RESULT</b>Eleven RCTs with 972 patients were included in this review. Only one research reported the mortality rate. None of the trials mentioned dependency of the patients during the follow-up period. The results of Meta analysis were listed as follows. Compared with normal treatment measures, total effective rate of 11 RCTs suggested that Shuxuetong were more effective with OR 4.46, 95% CI [3.02-6.59]. A greater difference in patients using Shuxuetong injection was found in 7 RCTs about the NDS with MD 5.86, 95% CI [4.80-6.93], compared with normal treatment measures. Researches with ADR/AE information of Shuxuetong injection showed that the symptoms of ADR/AE were moderate.</p><p><b>CONCLUSION</b>Conclusions from this review may have a high risk of bias because of the low quality of the researches, hence it was not adequate to draw any reliable conclusions about the efficacy of Shuxuetong injection in progressive ischaemic stroke. More trials with high quality are required in the following researches.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Medicamentos de Ervas Chinesas / Ensaios Clínicos Controlados Aleatórios como Assunto / Isquemia Encefálica / Acidente Vascular Cerebral / Tratamento Farmacológico Tipo de estudo: Ensaio Clínico Controlado / Revisões Sistemáticas Avaliadas Limite: Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Medicamentos de Ervas Chinesas / Ensaios Clínicos Controlados Aleatórios como Assunto / Isquemia Encefálica / Acidente Vascular Cerebral / Tratamento Farmacológico Tipo de estudo: Ensaio Clínico Controlado / Revisões Sistemáticas Avaliadas Limite: Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2012 Tipo de documento: Artigo