Effect of hepatitis C virus core protein on cholangiocarcinoma tissues' epithelial-mesenchymal transition / 中华外科杂志
Chinese Journal of Surgery
; (12): 1491-1493, 2007.
Article
em Zh
| WPRIM
| ID: wpr-338125
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of hepatitis C virus core protein on the infiltration and metastasis of cholangiocarcinoma tissues.</p><p><b>METHODS</b>From January 2001 to November 2006, 34 patients with cholangiocarcinoma who had intact follow-up data randomly were chosen. The expression of HCVc protein, epithelium markers and mesenchymal markers in cholangiocarcinoma tissues were examined by SP methods of immunohistochemistry, clinical-pathological data were recorded and analyzed.</p><p><b>RESULTS</b>The positive expression rate was observed in 47.1% for HCVc protein, 50% for N-cadherin, 44.1% for Vimentin, 55.9% for Fibronectin and the decreased expression rate was E-cadherin for 55.9%, alpha-catenin for 70.6%, beta-catenin for 55.9%. The positive expression of HCVc protein was associated with the decreased expression of E-cadherin, alpha-catenin and the positive expression of N-cadherin, Vimentin, Fibronectin (chi(2) = 4.480, 4.163, 4.250, 7.438, 12.260, P < 0.05). A positive-correlation between the expression of HCVc protein and metastasis of lymph nodes and other organs were found (chi(2) = 5.708, 4.163, P < 0.05).</p><p><b>CONCLUSION</b>HCVc protein might promote cholangiocarcinoma tissues' infiltration and metastasis by inducing it's epithelial-mesenchymal transition.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
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Fisiologia
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Virologia
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Imuno-Histoquímica
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Transformação Celular Neoplásica
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Proteínas do Core Viral
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Hepatite C
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Colangiocarcinoma
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Hepacivirus
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Epitélio
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Surgery
Ano de publicação:
2007
Tipo de documento:
Article