Effect of genetic polymorphism of MTNR1A gene on adolescent idiopathic scoliosis / 中华外科杂志
Chinese Journal of Surgery
;
(12): 1264-1266, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-338177
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether the MTNR1A gene promotor polymorphism (rs2119882) are associated with the occurrence or curve severity of adolescent idiopathic scoliosis (AIS).</p><p><b>METHODS</b>226 AIS patients and 277 normal controls were recruited. The maximum Cobb angles were recorded in AIS patients. PCR-RFLP was used for the genotyping.</p><p><b>RESULTS</b>The genotype and allele frequency distribution were comparable between AIS and normal control, the mean maximum Cobb angle of different genotypes of rs2119882 were similar with each other among AIS patients.</p><p><b>CONCLUSION</b>The MTNR1A gene promoter polymorphism was neither associated with the occurrence nor the curve severity of AIS.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Escoliose
/
Polimorfismo de Fragmento de Restrição
/
Reação em Cadeia da Polimerase
/
Predisposição Genética para Doença
/
Receptor MT1 de Melatonina
/
Frequência do Gene
/
Genética
/
Genótipo
Limite:
Adolescente
/
Adulto
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Surgery
Ano de publicação:
2007
Tipo de documento:
Artigo
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