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Expression and significance of survivin protein, PTEN in prostatic cancer / 中华男科学杂志
National Journal of Andrology ; (12): 346-351, 2006.
Artigo em Chinês | WPRIM | ID: wpr-338295
ABSTRACT
<p><b>OBJECTIVE</b>To study the expressions of survivin, PTEN and their relationships with tissue grade and pathology stage in prostatic carcinoma (PCa).</p><p><b>METHODS</b>The immunohistological staining was used to evaluated the expressions of survivin protein and PTEN in 43 case of prostatic carcinoma (PCa) and 5 cases of benign prostatic hyperplasia (BPH).</p><p><b>RESULTS</b>The positive rate of survivin protein was 81.40%. Expression of survivin protein in 5 case of BPH was negative. The positive rate of PTEN was 30.23%, and the higher the grade and the clinical stage of tumors were, the lower the expression of PTEN was, PTEN of 5 case of BPH was positive.</p><p><b>CONCLUSION</b>The positively correlation was found between the abnormal expressions of survivin protein, PTEN and the biological behavior of prostatic carcinoma (PCa). Detection of survivin combined with PTEN is valuable for diagnosing PCa, and evaluating malignancy extent and prognosis.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Prognóstico / Neoplasias da Próstata / Imuno-Histoquímica / PTEN Fosfo-Hidrolase / Proteínas Inibidoras de Apoptose / Metabolismo / Proteínas Associadas aos Microtúbulos / Proteínas de Neoplasias Tipo de estudo: Estudo prognóstico Limite: Idoso / Humanos / Masculino Idioma: Chinês Revista: National Journal of Andrology Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Prognóstico / Neoplasias da Próstata / Imuno-Histoquímica / PTEN Fosfo-Hidrolase / Proteínas Inibidoras de Apoptose / Metabolismo / Proteínas Associadas aos Microtúbulos / Proteínas de Neoplasias Tipo de estudo: Estudo prognóstico Limite: Idoso / Humanos / Masculino Idioma: Chinês Revista: National Journal of Andrology Ano de publicação: 2006 Tipo de documento: Artigo