Expression of cyclooxygenase-2 and vascular endothelial growth factor in human prostate cancer and its significance / 中华男科学杂志
National Journal of Andrology
;
(12): 207-210, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-338329
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate expressions of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in primary prostate cancer and its clinical significance.</p><p><b>METHODS</b>Expressions of COX-2 and VEGF were detected by immunohistochemical assay in tissues of 40 prostate cancer and 10 benign prostatic hyperplasia samples.</p><p><b>RESULTS</b>COX-2 and VEGF levels in prostate cancer were much higher than those in BPH. The degrees of cancer malignancy and invasion positively correlated with the expressions of COX-2 and VEGF. COX-2 level positively correlated with VEGF level.</p><p><b>CONCLUSION</b>The abnormal expression of COX-2 plays an important role in the development of primary prostate cancer. COX-2 and VEGF are good molecular markers of prostate cancer which are hopeful to be used for the assistant diagnosis and the prediction of prognosis of prostate cancer.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
/
Hiperplasia Prostática
/
Neoplasias da Próstata
/
Imuno-Histoquímica
/
Fator A de Crescimento do Endotélio Vascular
/
Ciclo-Oxigenase 2
/
Metabolismo
/
Estadiamento de Neoplasias
Tipo de estudo:
Estudo prognóstico
Limite:
Idoso
/
Aged80
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2006
Tipo de documento:
Artigo
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