Diagnosis of colon cancer with Fourier transform infrared spectroscopy on the malignant colon tissue samples / 中华医学杂志(英文版)

ABSTRACT

<p><b>BACKGROUND</b>Fourier transform infrared spectroscopy (FT-IR) combined with chemometrics discriminant analysis technology could improve diagnosis. The present study aimed to evaluate the effects of FT-IR on malignant colon tissue samples in diagnosis of colon cancer.</p><p><b>METHODS</b>Principal component analysis (PCA) and support vector machine classification were used to discriminate FT-IR spectra from malignant and normal tissue. Colon tissues samples from 85 patients were used to demonstrate the procedure.</p><p><b>RESULTS</b>For this set of colon spectral data, the sensitivity and specificity of the support vector machine (SVM) classification were found both higher than 90%.</p><p><b>CONCLUSIONS</b>FT-IR provided important information about cancerous tissue, which could be used to discriminate malignant from normal tissues. The combination of PCA and SVM classification indicated that FT-IR has a potential clinical application in diagnosis of colon cancer.</p>