Expression of nucleophosmin in glandular epithelium of non-pregnant human endometrium during the menstrual cycle / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2448-2451, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-338529
ABSTRACT
<p><b>BACKGROUND</b>Nucleophosmin plays a critical role in embryonic development. This study aimed to examine the expression pattern of nucleophosmin in glandular epithelium of human endometrium during the menstrual cycle.</p><p><b>METHODS</b>Endometrial tissues used for this study were obtained from 46 non-pregnant patients who underwent hysterectomy which had been performed to treat benign diseases. Nucleophosmin expression was assessed by in situ hybridization and immunohistochemistry.</p><p><b>RESULTS</b>At the early-, mid- and late-proliferative phase, nucleophosmin mRNA was highly expressed in glandular epithelium of human endometrium. At the secretory phase, the expression of nucleophosmin mRNA was reduced in glandular epithelium in early-secretory phase, and the expression in mid- and late-secretory phases was not detected. Similarly, nucleophosmin protein was strongly expressed in endometrial glands throughout the proliferative phase, but was gradually reduced during secretory phase.</p><p><b>CONCLUSION</b>Nucleophosmin mRNA and protein are expressed in glandular epithelium of human endometrium throughout the menstrual cycle.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Técnicas In Vitro
/
Imuno-Histoquímica
/
Proteínas Nucleares
/
Hibridização In Situ
/
Endométrio
/
Genética
/
Ciclo Menstrual
/
Metabolismo
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2011
Tipo de documento:
Artigo
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