Protective effect of NEP on Abeta-induced apoptosis in PC12 cells / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 722-725, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-338931
ABSTRACT
<p><b>OBJECTIVE</b>To identify the effect of NEP on Abeta -induced apoptosis in PC12 cells.</p><p><b>METHODS</b>PC12 cells that stably express NEP is generated and the effect of NEP on the process of apoptosis induced by Abeta is analyzed, including the viability of the cells, the production of LDH, ROS and ATP, the activity of Caspase-3.</p><p><b>RESULTS</b>NEP could improve the viability of cells and the production of ATP, inhibit the release of LDH and ROS. In the same time, the activity of caspase-3 descended (P < 0.05). But iNEP had not significant effect on cells apoptosis (P > 0.05).</p><p><b>CONCLUSION</b>NEP has the protective effect on Abeta-induced apoptosis in PC12 cells.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Endopeptidases
/
Farmacologia
/
Transfecção
/
Peptídeos beta-Amiloides
/
Células PC12
/
Apoptose
/
Caspase 3
/
Genética
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2007
Tipo de documento:
Artigo
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