Construction of a non-redundant human SH2 domain database / 基因组蛋白质组与生物信息学报·英文版
Genomics, Proteomics & Bioinformatics
;
(4): 119-122, 2004.
Artigo
em Inglês
| WPRIM
| ID: wpr-339487
ABSTRACT
Domain database is essential for domain property research. Eliminating redundant information in database query is very important for database quality. Here we report the manual construction of a non-redundant human SH2 domain database. There are 119 human SH2 domains in 110 SH2-containing proteins. Human SH2s were aligned with ClustalX, and a homologous tree was generated. In this tree, proteins with similar known function were classified into the same group. Some proteins in the same group have been reported to have similar binding motifs experimentally. The tree might provide clues about possible functions of hypothetical proteins for further experimental verification.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dados de Sequência Molecular
/
Alinhamento de Sequência
/
Sequência de Aminoácidos
/
Domínios de Homologia de src
/
Biologia Computacional
/
Bases de Dados de Proteínas
/
Genética
Limite:
Humanos
Idioma:
Inglês
Revista:
Genomics, Proteomics & Bioinformatics
Ano de publicação:
2004
Tipo de documento:
Artigo
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