Evolution and variation of the SARS-CoV genome / 基因组蛋白质组与生物信息学报·英文版
Genomics, Proteomics & Bioinformatics
;
(4): 216-225, 2003.
Artigo
em Inglês
| WPRIM
| ID: wpr-339504
ABSTRACT
Knowledge of the evolution of pathogens is of great medical and biological significance to the prevention, diagnosis, and therapy of infectious diseases. In order to understand the origin and evolution of the SARS-CoV (severe acute respiratory syndrome-associated coronavirus), we collected complete genome sequences of all viruses available in GenBank, and made comparative analyses with the SARS-CoV. Genomic signature analysis demonstrates that the coronaviruses all take the TGTT as their richest tetranucleotide except the SARS-CoV. A detailed analysis of the forty-two complete SARS-CoV genome sequences revealed the existence of two distinct genotypes, and showed that these isolates could be classified into four groups. Our manual analysis of the BLASTN results demonstrates that the HE (hemagglutinin-esterase) gene exists in the SARS-CoV, and many mutations made it unfamiliar to us.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Filogenia
/
Composição de Bases
/
Variação Genética
/
Códon
/
Análise Mutacional de DNA
/
Genoma Viral
/
Evolução Molecular
/
Biologia Computacional
/
Substituição de Aminoácidos
/
Motivos de Aminoácidos
Tipo de estudo:
Guia de Prática Clínica
Idioma:
Inglês
Revista:
Genomics, Proteomics & Bioinformatics
Ano de publicação:
2003
Tipo de documento:
Artigo
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