Advances in the study of SR protein family / 基因组蛋白质组与生物信息学报·英文版
Genomics, Proteomics & Bioinformatics
;
(4): 2-8, 2003.
Artigo
em Inglês
| WPRIM
| ID: wpr-339529
ABSTRACT
The name of SR proteins is derived from their typical RS domain that is rich in serine (Ser, S) and arginine (Arg, R). They are conserved in evolution. Up to now, 10 members of the SR protein family have been identified in humans. SR proteins contain one or two RNA binding motifs aside from the RS domain, and also possess special biochemical and immunological features. As to the functions of SR proteins, they facilitate the recruitment of the components of splicesome via protein-protein interaction to prompt the assembly of early splicesome; while in alternative splicing, tissue-specifically expressed SR protein along with the relative ratio of SR protein and heterogeneous nuclear ribonucleoprotein (hnRNP) is composed of two main regulative mechanisms to alternative splicing. Almost all of the biochemical functions are regulated by reversible phosphorylation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosforilação
/
Ligação Proteica
/
Conformação Proteica
/
RNA
/
Química
/
Spliceossomos
/
Estrutura Terciária de Proteína
/
Processamento Alternativo
/
Evolução Molecular
/
Motivos de Aminoácidos
Limite:
Humanos
Idioma:
Inglês
Revista:
Genomics, Proteomics & Bioinformatics
Ano de publicação:
2003
Tipo de documento:
Artigo
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