Expression of c-kit and Cx43 in neonates with spontaneous gastric perforation / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 787-789, 2011.
Article
em Zh
| WPRIM
| ID: wpr-339531
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical significance of interstitial cell of Cajal (ICC) in spontaneous neonatal gastric perforation by examining the expression of c-kit and Cx43 in neonates with this disorder.</p><p><b>METHODS</b>The gastric specimens of 19 cases of neonatal gastric perforation from 2001 to 2010 and 8 cases of accidental death without digestive tract malformations (control) were collected. Immunohistochemical staining was employed to examine the expression of c-kit and Cx43 (immunomarkers of ICCs) in gastric tissues.</p><p><b>RESULTS</b>The muscular layer of the stomach wall became thinner or deficient in the gastric perforation group. C-kit and Cx43 positive cells in gastric tissues decreased significantly in the gastric perforation group compared with those in the control group (P<0.01).</p><p><b>CONCLUSIONS</b>The development of spontaneous neonatal gastric perforation is associated with the decreased quantity of ICCs and damaged gap junction structure of the stomach wall.</p>
Texto completo:
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Índice:
WPRIM
Assunto principal:
Patologia
/
Ruptura Espontânea
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Estômago
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Ruptura Gástrica
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Química
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Conexina 43
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Proteínas Proto-Oncogênicas c-kit
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Células Intersticiais de Cajal
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Metabolismo
Limite:
Female
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Humans
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Male
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Newborn
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2011
Tipo de documento:
Article