Intestinal inflammation-induced child growth failure: immunologic and endocrine mechanisms / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 767-771, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-339536
ABSTRACT
Faltering linear growth is commonly encountered in children with intestinal inflammation. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are important regulators of postnatal longitudinal bone growth. Inhibition of GH/IGF axis will result in growth failure in young children. Pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) abnormally increase in children with intestinal inflammation, and may affect linear growth both systemically and locally at the level of the growth plate though disturbing the GH/IGF axis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Desenvolvimento Ósseo
/
Somatomedinas
/
Citocinas
/
Hormônio do Crescimento Humano
/
Enterite
/
Transtornos do Crescimento
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2011
Tipo de documento:
Artigo
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