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Effects of glial cell line-derived neurotrophic factor and memantine on long-term prognosis in neonatal rats with periventricular leukomalacia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 743-746, 2011.
Artigo em Chinês | WPRIM | ID: wpr-339543
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effects of glial cell line-derived neurotrophic factor (GDNF) and memantine on the long-term prognosis in neonatal rats with ischemia-induced periventricular leukomalacia (PVL).</p><p><b>METHODS</b>Thirty-two 5-day-old neonatal rats were randomly divided into 4 groups sham-operated, PVL, GDNF-treated and memantine-treated. PVL was induced by right carotid artery ligation and hypoxia in the PVL, GDNF-treated and memantine-treated groups. GDNF (100 μg/kg) or memantine (20 mg/kg) was injected in the two treatment groups immediately after PVL inducement. The weight of the rats was measured immediately before and after hypoxia ischemia (HI). Both of Morris water maze test and Rivlin inclined plane test were performed at 26 days old (21 days after HI). The values of the escape latency (EL) and swimming distance, and the maximum inclined plane degree which the rats could stand at least 5 seconds were compared among the four groups.</p><p><b>RESULTS</b>The lower weight, the prolonged mean values of EL and swimming distance and the reduced maximum inclined plane degree were observed in the PVL group compared to those in the sham-operated, GDNF-treated and memantine-treated groups. There were no significant differences in the weight, the values of EI and swimming distance and the maximum inclined plane degree between the two treatment groups and the sham-operated group.</p><p><b>CONCLUSIONS</b>The administration of either GDNF or memantine can markedly increase the abilities of spatial discrimination,learning and memory, and motor coordination, promote weight gain, and improve long-term prognosis in rats with PVL.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Psicologia / Peso Corporal / Leucomalácia Periventricular / Memantina / Aprendizagem em Labirinto / Antagonistas de Aminoácidos Excitatórios / Usos Terapêuticos / Tratamento Farmacológico / Fator Neurotrófico Derivado de Linhagem de Célula Glial / Animais Recém-Nascidos Tipo de estudo: Estudo prognóstico Limite: Animais / Humanos Idioma: Chinês Revista: Chinese Journal of Contemporary Pediatrics Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Psicologia / Peso Corporal / Leucomalácia Periventricular / Memantina / Aprendizagem em Labirinto / Antagonistas de Aminoácidos Excitatórios / Usos Terapêuticos / Tratamento Farmacológico / Fator Neurotrófico Derivado de Linhagem de Célula Glial / Animais Recém-Nascidos Tipo de estudo: Estudo prognóstico Limite: Animais / Humanos Idioma: Chinês Revista: Chinese Journal of Contemporary Pediatrics Ano de publicação: 2011 Tipo de documento: Artigo