Chromosome analysis in 92 children with congenital mental retardation / 中国当代儿科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the chromosome karyotypes in children with mental retardation.</p><p><b>METHODS</b>The peripheral blood lymphocytes from 92 children with congenital mental retardation were cultured and analysed by the G-band technique.</p><p><b>RESULTS</b>Of the 92 cases, 43 cases (47%) showed chromosome abnormalities. Autosomal abnormalities were found in 35 cases (38%) and sex chromosome abnormalities were found in 8 cases (9%). A novel abnormal karyotype 45, XX, psu dic (11;9) (p15;p24) was found in a child.</p><p><b>CONCLUSIONS</b>Chromosome abnormalities may be important cytogenetic factors for congenital mental retardation. Cytogenetic chromosome karyotypic analysis appears to be an important method for genetic screening of congenital mental retardation.</p>