The protective effects of IPC on isolated myocardial ischemia/reperfusion injury in rats / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To investigate the protective effects and mechanism of IPC on myocardial ischemia/reperfusion injury.</p><p><b>METHODS</b>Effects of IPC on arrhythmia and coronary blood flow and the release of AST, CPK, LDH, SOD and LFO at different time after ischemia/reperfusion injury in rat Langendorff hearts were studied.</p><p><b>RESULTS</b>IPC decreased the release of AST, CPK and LDH and increased myocardial SOD activity and decreased LPO level. IPC also inhibited ischemia/reperfusion arrhythmias and increased coronary blood flow.</p><p><b>CONCLUSION</b>The results showed that IPC had well protective effects on myocardial ischemia/reperfusion injury.</p>