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The proarrhythmic effects of autoantibody against beta1 adrenergic receptor / 中国应用生理学杂志
Chinese Journal of Applied Physiology ; (6): 257-260, 2010.
Artigo em Chinês | WPRIM | ID: wpr-340177
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution characteristics of autoantibody against beta1 adrenergic receptor (beta1 AR) in the sera of arrhythmia patients and whether the autoantibody could induce arrhythmia.</p><p><b>METHODS</b>Healthy subjects and patients with arrhythmia or coronary artery disease were chosen. The autoantibody against beta1 AR in the sera was screened by enzyme-linked immunosorbent assay (ELISA). IgG in the positive autoantibody sera from arrhythmia patients were purified and administrated to normal rats; then the ECGs were dynamic monitored.</p><p><b>RESULTS</b>The positive rate of autoantibody against beta1 AR in arrhythmia patients was 52.8%, which was significantly higher than that in coronary heart disease group (24%, P < 0.01) and healthy people group (5%, P < 0.01), respectively. Moreover, the autoantibody against beta1 AR could lead to the occurring of arrhythmia in normal rats, most of which were ventricular arrhythmia.</p><p><b>CONCLUSION</b>In the sera of arrhythmia patients, the autoantibody against beta1 AR has a high titer and it could lead to the arrhythmia of rats in vivo.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Arritmias Cardíacas / Autoanticorpos / Sangue / Imunoglobulina G / Estudos de Casos e Controles / Receptores Adrenérgicos beta 1 / Alergia e Imunologia Tipo de estudo: Estudo observacional Limite: Animais / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Applied Physiology Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Arritmias Cardíacas / Autoanticorpos / Sangue / Imunoglobulina G / Estudos de Casos e Controles / Receptores Adrenérgicos beta 1 / Alergia e Imunologia Tipo de estudo: Estudo observacional Limite: Animais / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Applied Physiology Ano de publicação: 2010 Tipo de documento: Artigo