The proarrhythmic effects of autoantibody against beta1 adrenergic receptor / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 257-260, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-340177
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution characteristics of autoantibody against beta1 adrenergic receptor (beta1 AR) in the sera of arrhythmia patients and whether the autoantibody could induce arrhythmia.</p><p><b>METHODS</b>Healthy subjects and patients with arrhythmia or coronary artery disease were chosen. The autoantibody against beta1 AR in the sera was screened by enzyme-linked immunosorbent assay (ELISA). IgG in the positive autoantibody sera from arrhythmia patients were purified and administrated to normal rats; then the ECGs were dynamic monitored.</p><p><b>RESULTS</b>The positive rate of autoantibody against beta1 AR in arrhythmia patients was 52.8%, which was significantly higher than that in coronary heart disease group (24%, P < 0.01) and healthy people group (5%, P < 0.01), respectively. Moreover, the autoantibody against beta1 AR could lead to the occurring of arrhythmia in normal rats, most of which were ventricular arrhythmia.</p><p><b>CONCLUSION</b>In the sera of arrhythmia patients, the autoantibody against beta1 AR has a high titer and it could lead to the arrhythmia of rats in vivo.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Arritmias Cardíacas
/
Autoanticorpos
/
Sangue
/
Imunoglobulina G
/
Estudos de Casos e Controles
/
Receptores Adrenérgicos beta 1
/
Alergia e Imunologia
Tipo de estudo:
Estudo observacional
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2010
Tipo de documento:
Artigo
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