Lymphocyte GRK2 expression of the very elderly with chronic heart failure / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 207-209, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-340193
ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation of lymphocyte G protein-coupled receptor kinases 2 (GRK2) expression of the very elderly with chronic heart failure (HF) and heart ejection fraction (EF).</p><p><b>METHODS</b>16 elderly patients with chronic heart failure were divided into 2 groups as following EF < 45% (n=7), EF > or = 45% (n=9); and health elderly as control (n=8). Lymphocytes were obtained from blood, reverse transcription polymerase chain reaction were used to measure GRK2 mRNA levels.</p><p><b>RESULTS</b>Lymphocyte GRK2 mRNA levels of EF < 45% group were higher than that of EF > 45% group, which were greater than that of control.</p><p><b>CONCLUSION</b>Elevation of lymphocyte GRK2 levels in HF is associated with heart EF, lymphocytes may provide a surrogate for monitoring cardiac GRK2 in human HF.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Volume Sistólico
/
Sangue
/
RNA Mensageiro
/
Linfócitos
/
Doença Crônica
/
Quinase 2 de Receptor Acoplado a Proteína G
/
Genética
/
Insuficiência Cardíaca
/
Metabolismo
Limite:
Idoso
/
Aged80
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2010
Tipo de documento:
Artigo
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