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The subgroup change of nitric oxide synthase in earlier period with cerebral ischemia/reperfusion in rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology ; (6): 144-146, 2010.
Artigo em Chinês | WPRIM | ID: wpr-340212
ABSTRACT
<p><b>OBJECTIVE</b>To observe the expression of endothelial nitric oxide synthase (eNOS)and nervous nitric oxide synthase (nNOS) in rats during cerebral ischemia/reperfusion (CI/R) and study if change will be happen in subgroup between eNOS and nNOS during earlier period of CI/R.</p><p><b>METHODS</b>A total of 60 Wistar rats weighting 200-280 g, supplied by Animal Center of China Medical University, were divided into 6 groups (n=10) (sham operation group; ischemia 1 h, 2 h group; reperfusion 0.5 h, 1 h, 2 h group). Female and male was half-and-half. Cerebral ischemia/reperfusion injury was induced by a 2-hour suture occlusion of the unilateral middle cerebral artery, immediately after suture withdrawal to allow reperfusion, eNOS and nNOS expressions were examined by the method of immunohistochemistry.</p><p><b>RESULTS</b>eNOS expressions increased in 1-hour during ischemia, keeping up with decreasing until reperfusion 2-hour. While nNOS expressions increased in 2-hour between ischemia and reperfusion.</p><p><b>CONCLUSION</b>Changes of expression between eNOS and nNOS in rats during cerebral ischemia/reperfusion are different. This may be related with ischemia and reperfusion injury.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fatores de Tempo / Encéfalo / Traumatismo por Reperfusão / Isquemia Encefálica / Ratos Wistar / Óxido Nítrico Sintase Tipo I / Óxido Nítrico Sintase Tipo III / Metabolismo Limite: Animais Idioma: Chinês Revista: Chinese Journal of Applied Physiology Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fatores de Tempo / Encéfalo / Traumatismo por Reperfusão / Isquemia Encefálica / Ratos Wistar / Óxido Nítrico Sintase Tipo I / Óxido Nítrico Sintase Tipo III / Metabolismo Limite: Animais Idioma: Chinês Revista: Chinese Journal of Applied Physiology Ano de publicação: 2010 Tipo de documento: Artigo