Association between interleukin-1β C+3953T and genetic susceptibility to spontaneous preterm birth: a case-control study / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1123-1129, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-340554
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between interleukin-1β (IL-1β) C+3953T and genetic susceptibility to spontaneous preterm birth (SPTB).</p><p><b>METHODS</b>In this case-control study, 753 SPTB neonates were enrolled in the case group and 681 full-term neonates were enrolled in the control group. The latest Sequenom MassARRAY®SNP detection technique was used for the typing of single nucleotide polymorphisms (SNP) of IL-1β C+3953T.</p><p><b>RESULTS</b>Compared with those carrying CC genotype of IL-1β C+3953T, the neonates who carried at least one T allele (CT+TT genotype) had significantly increased risks of SPTB, SPTB complicated by premature rupture of membranes, and mild preterm birth.</p><p><b>CONCLUSIONS</b>In the Chinese population, IL-1β C+3953T has significant genetic association with an increased risk of SPTB. The identification of this SNP helps to prevent SPTB and clarify the causes and pathogenesis of SPTB.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estudos de Casos e Controles
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Nascimento Prematuro
/
Interleucina-1beta
/
Genética
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
/
Recém-Nascido
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2016
Tipo de documento:
Artigo
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