Preparation of interferon-alpha-loaded poly-L-lactic acid lamellar particles / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 559-562, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-340969
ABSTRACT
Lamellar particles(lamellae) were prepared by non-solvent precipitation from crystalic poly-L-lactic acid (PLLA). The PLLA lamellae exhibite a diamond or stepped irregular shape with a size range between 3-5 microns. Prepared without any surfactants and dispersing agents, the lamellar particles have clean surface, which is advantageous for the adsorption of proteins. The PLLA lamellar particles adsorbed protein cytokine interferon-alpha (IFN-alpha) with an adsorption efficiency of > or = 95%. The release of loaded IFN could continue for more than 10 days. The cell incubation experiments showed that the PLLA lamellar particles were easy to be phagocytosed by macrophages. The immunological experiments showed that the biological activity of IFN-alpha loaded on the PLLA lamellar particle was effectively retained.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho da Partícula
/
Farmacologia
/
Poliésteres
/
Polímeros
/
Portadores de Fármacos
/
Química
/
Química Farmacêutica
/
Interferon-alfa
/
Ácido Láctico
/
Adsorção
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2002
Tipo de documento:
Artigo
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