Reduced Expression of PTEN Protein and Its Prognostic Significance in the Gastrointestinal Stromal Tumor / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
;
(6): 165-169, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-341103
ABSTRACT
Little is reported about the role of PTEN gene in the progression and prognosis of GISTs.This study examined the clinical implications of the tumor suppressor gene PTEN as a prognostic factor in the GISTs.Immunohistological staining and immunoblotting were employed to examine the PTEN protein expression,and its association with clinical measures.Clinicopathological features were reviewed by a retrospective examination of medical records.Reduced PTEN expression was significantly associated with tumor diameter,mitotic figure count,metastasis and pathological stage of tumor(P<0.05),and was not correlated with age,gender and tumor location(P>0.05).The 3-year survival rate of the patients with reduced PTEN expression was significantly lower than those with high PTEN expression(P<0.01).These results suggest that the expression of PTEN gene was significantly linked with the progression and metastasis of GISTs and it is an independent prognostic factor.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Ano de publicação:
2010
Tipo de documento:
Artigo
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