Helicobacter pylori infection enhances atherosclerosis in high-cholesterol diet fed C57BL/6 mice / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 259-263, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-341243
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the impacts of Helicobacter pylori (H. pylori) infection on atherosclerosis and plasma lipid levels in high-cholesterol diet fed C57BL/6 mice.</p><p><b>METHOD</b>Female C57BL/6 mice were randomly divided into 4 groups (n = 12 each) fed with normal chow diet (A), infected with H. pylori (B), fed with high-cholesterol diet (C) and infected with H. pylori and fed with high-cholesterol diet (D). After 52 weeks, plasma levels of lipids were measured and aortic atherosclerosis was observed. The ureA, ureC, cagA and vacA DNA were also detected by PCR in the aortic arteries.</p><p><b>RESULT</b>(1) Prevalence of atherosclerosis was similar between group C and D (91.6% vs. 100%, P > 0.05) while there was no atherosclerosis in group A and B. H. pylori infected mice showed more obvious inflammation in gastric mucosa than mice without H. pylori infection. (2) The plasma levels of triglyceride, total cholesterol and LDL were higher and HDL was lower in group B, C and D than those in group A and in group D than in group C (all P < 0.05). (3) Roberts & Thompson scores and number of foam cells in plaques were significantly higher in group D compared with those in group C (all P < 0.05). (4) ureC DNA was detected in 5 out of 12 aortic arteries of mice in group D but not in group A, B and C.</p><p><b>CONCLUSION</b>Our results suggested that H. pylori infection might enhance the atherosclerotic lesion formation in this mouse model.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Proteínas de Bactérias
/
Toxinas Bacterianas
/
Triglicerídeos
/
Urease
/
Sangue
/
DNA Bacteriano
/
Colesterol na Dieta
/
Colesterol
/
Helicobacter pylori
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2010
Tipo de documento:
Artigo
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