Studies on the association between beta 2-glycoprotein I and hepatotropism of hepatitis B virus / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 569-571, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-341299
ABSTRACT
<p><b>OBJECTIVE</b>To further study the binding character of hepatitis B surface antigen (HBsAg) and beta 2-glycoprotein I (beta2GP I) and to explore whether beta2GP I plays an important role in the hepatotropism of hepatitis B virus.</p><p><b>METHODS</b>Using Western blot technique, we observed the binding character of the HBsAg with reduced and non-reduced beta2GP I.</p><p><b>RESULTS</b>rHBsAgs with reduced and non-reduced beta2GP I showed identical binding activity.</p><p><b>CONCLUSIONS</b>The binding activity of HBsAg is dependent on tandem residues, but not on conformational structures of beta2GP I. There is a specific binding between HBV and beta2GP I, which may play an important role in HBV infection and is one of the reasons of hepatotropism of HBV.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Virologia
/
Virulência
/
Sangue
/
Proteínas do Envelope Viral
/
Vírus da Hepatite B
/
Beta 2-Glicoproteína I
/
Hepatite B
/
Antígenos de Superfície da Hepatite B
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2006
Tipo de documento:
Artigo
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