A Case of Polycythemia Vera with a JAK2V617F Mutation Combined with Smoldering Myeloma / 대한내과학회지
Korean Journal of Medicine
;
: 308-312, 2013.
Artigo
em Coreano
| WPRIM
| ID: wpr-34181
ABSTRACT
The lymphoproliferative disease multiple myeloma and the myeloproliferative disease polycythemia vera have different pathogenic mechanisms and different natural courses. Thus, the concomitant development of these two diseases in the same individual is rare. In most previously reported cases of both diseases, one disease was assumed to be a secondary malignancy caused by chemotherapy for the other primary disease. Our case was diagnosed as smoldering myeloma based on increased bone marrow plasma cell numbers and monoclonal gammopathy during a regular follow-up visit for JAK2V617F mutation-positive polycythemia vera, which had not been treated except with phlebotomy. This case provides useful clues for understanding the pathogenesis of these two hematological malignancies and the association between them. Here, we report a case of polycythemia vera with a JAK2V617F mutation combined with smoldering myeloma and discuss the clinical significance and pathogenic association between these disorders of different lineages, along with a literature review.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Paraproteinemias
/
Plasmócitos
/
Policitemia
/
Policitemia Vera
/
Medula Óssea
/
Seguimentos
/
Flebotomia
/
Neoplasias Hematológicas
/
Mieloma Múltiplo
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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