Coumarins from Leonurus japonicus and their anti-platelet aggregative activity / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 4356-4359, 2014.
Article
em Zh
| WPRIM
| ID: wpr-341854
Biblioteca responsável:
WPRO
ABSTRACT
Chemical constituents of Leonurus japonicus were isolated and purified by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, MCI, and Rp C18. Structures of the isolates were determined by spectroscopic analysis as 10 coumarins: bergapten (1), xanthotoxin (2), isopimpinellin (3), isogosferal (4), imperatorin (5), meransin hydrate(6), isomeranzin(7), murrayone(8) , auraptenol(9), and osthol(10). In addition to compound 9, the others were isolated from the genus Leonurus for the first time. In the in vitro assay, compounds 4 and 8 significantly inhibited the abnormal increase of platelet aggregation induced by ADP.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
/
Plaquetas
/
Inibidores da Agregação Plaquetária
/
Química
/
Agregação Plaquetária
/
Cumarínicos
/
Leonurus
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2014
Tipo de documento:
Article