Effect of alahistidine on brain histamine content and seizure development / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 197-200, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-341908
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of alahistidine on brain histamine content and seizure development.</p><p><b>METHODS</b>The kindling seizure was induced by ip injection with subconvulsant dose of pentylenetetrazole every 48 h. Monoamines and their metabolites were measured using a HPLC system and fluorometric assay.</p><p><b>RESULT</b>Chronic low histamine feeding markedly decreased histamine content in cortex and hypothalamus, and promoted seizure development induced by pentylenetetrazole. However, alahistidine feed reversed the decreased histamine content and slowed seizure development caused by low histamine feed. Both low histamine and alahistidine feed had no effect on norepinephrine, dopamine and its metabolites.</p><p><b>CONCLUSION</b>Alahistidine may affect histaminergic system and seizure development.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pentilenotetrazol
/
Farmacologia
/
Fisiologia
/
Convulsões
/
Química Encefálica
/
Carnosina
/
Receptores Histamínicos H1
/
Histamina
/
Ratos Sprague-Dawley
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2004
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS