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Growth-suppression effect of hydroxyurea on meningioma cells in vitro / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 129-132, 2004.
Artigo em Chinês | WPRIM | ID: wpr-341925
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the tumor-suppression effect of hydroxyurea on meningioma cells and its possible mechanism.</p><p><b>METHODS</b>The meningioma cells were cultured in medium containing varied doses of hydroxyurea (5x10(-3)mol/L, 5x10(-4)mol/L, 5x10(-5)mol/L), the cell growth was measured by MTT method, cell apoptosis was observed with flow cytometry (FCM).</p><p><b>RESULTS</b>MTT measurement demonstrated that the administration of hydroxyurea led to a dose-dependent suppression in cell proliferation and FCM showed a dose-dependent increase in apoptosis rate.</p><p><b>CONCLUSION</b>Hydroxyurea can inhibit meningioma cell growth in vitro, which is most likely associated with apoptosis of the tumor cells.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Farmacologia / Divisão Celular / Apoptose / Linhagem Celular Tumoral / Relação Dose-Resposta a Droga / Tratamento Farmacológico / Citometria de Fluxo / Hidroxiureia / Meningioma Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Zhejiang University. Medical sciences Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Farmacologia / Divisão Celular / Apoptose / Linhagem Celular Tumoral / Relação Dose-Resposta a Droga / Tratamento Farmacológico / Citometria de Fluxo / Hidroxiureia / Meningioma Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Zhejiang University. Medical sciences Ano de publicação: 2004 Tipo de documento: Artigo