Growth-suppression effect of hydroxyurea on meningioma cells in vitro / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 129-132, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-341925
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the tumor-suppression effect of hydroxyurea on meningioma cells and its possible mechanism.</p><p><b>METHODS</b>The meningioma cells were cultured in medium containing varied doses of hydroxyurea (5x10(-3)mol/L, 5x10(-4)mol/L, 5x10(-5)mol/L), the cell growth was measured by MTT method, cell apoptosis was observed with flow cytometry (FCM).</p><p><b>RESULTS</b>MTT measurement demonstrated that the administration of hydroxyurea led to a dose-dependent suppression in cell proliferation and FCM showed a dose-dependent increase in apoptosis rate.</p><p><b>CONCLUSION</b>Hydroxyurea can inhibit meningioma cell growth in vitro, which is most likely associated with apoptosis of the tumor cells.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Divisão Celular
/
Apoptose
/
Linhagem Celular Tumoral
/
Relação Dose-Resposta a Droga
/
Tratamento Farmacológico
/
Citometria de Fluxo
/
Hidroxiureia
/
Meningioma
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2004
Tipo de documento:
Artigo
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