Effects of sodium hyaluronate on growth and adhesion of two human colorectal cancer cell lines in vitro / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 525-528, 2003.
Article
em Zh
| WPRIM
| ID: wpr-341961
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of sodium hyaluronate on the growth and adhesion of colorectal cancer cells.</p><p><b>METHODS</b>Human colorectal cancer cell lines SW620 and Colo205 were treated with sodium hyaluronate (25 -2,500 microg/ml), and cancer cell proliferation was measured by MTT assay in vitro. Flow-cytometric analysis was applied to detect expression of CD44 on SW620 and Colo205 cells.</p><p><b>RESULT</b>In vitro sodium hyaluronate enhanced proliferation of Colo205 cells, but it had no appreciable effect on SW620 growth under the same doses, Meantime, CD44 expression on cancer cells decreased compared with controls.</p><p><b>CONCLUSION</b>In vitro sodium hyaluronate has different effects on growth of different colorectal cancer cell lines, but can inhibit CD44 expression of colorectal cancer cells and influence their ability of adhesion.</p>
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Índice:
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Assunto principal:
Patologia
/
Farmacologia
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Neoplasias Colorretais
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Adesão Celular
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Divisão Celular
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Receptores de Hialuronatos
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Linhagem Celular Tumoral
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Ácido Hialurônico
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2003
Tipo de documento:
Article