Association between single nucleotide polymorphisms and wheat-dependent exercise-induced anaphylaxis in Chinese population / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1159-1165, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-342219
ABSTRACT
<p><b>BACKGROUND</b>Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a complex disease resulting from interaction of environmental and genetic factors. The aim of this study was to investigate the association of three single nucleotide polymorphisms (SNPs) (IL-4-C590T, IL-4RA A1727G and IL-10-A627C) with WDEIA.</p><p><b>METHODS</b>SNP genotyping was conducted among the case subset composing 51 patients with WDEIA and four control subsets by sequencing DNA yielded from polymerase chain reaction (PCR). Statistical analysis of genotype/allele's frequencies between cases and controls were carried out through Fisher's exact test with the software of SPSS16.0.</p><p><b>RESULTS</b>For IL-4-C590T, there were statistically significant differences of genotype frequencies in case-control 1 (P = 0.03) and case-control 4 (P = 0.001) and statistically significant differences of allele frequencies in three case-control models (case-control 1 OR = 4.27 (95%CI = 1.40 - 13.07), P = 0.009; case-control 3 OR = 1.99 (95%CI = 1.13 - 3.50), P = 0.02; case-control 4 OR = 2.39 (95%CI = 1.49 - 3.84), P = 0.001). All other association studies showed no statistically significant (P > 0.05).</p><p><b>CONCLUSIONS</b>IL-4-C590T may be related to the susceptibility of WDEIA, and the minor allele C might be a potential risk factor accounting for WDEIA. IL-4RA A1727G and IL-10-A627C might not be involved in the occurrence of WDEIA.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Triticum
/
Imunoglobulina E
/
Exercício Físico
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
/
Alergia e Imunologia
/
Frequência do Gene
/
Genética
/
Genótipo
Tipo de estudo:
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2013
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS